My thinking on the matter:
A three day pack should only need one change of clothes. If you're planning on an initial change from ( for example ) business attire to a set of rugged bugging out-wear, keep that initial change outside the BOB itself so you don't have to dig deeply for it.
First aid kit for a BOB should be basic and minimal to meet dire medical emergencies, not cover every circumstance.
A large ruck is more of an INCH bag rather than BOB
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